.Africa is the proposed Internet generic Top-Level Domain (gTLD) for the African and Pan African communities and users wherever they may reside. The .africa gTLD serves as a regional domain for individuals and entities based in and out of Africa.
The .Africa gTLD has not yet been delegated to any organization as registry operator. The .Africa application that was submitted by DotConnectAfrica Trust is now the subject of an unresolved disagreement with ICANN (DCA Trust vs ICANN) following an Independent Review Panel (IRP) Process that was invoked by DCA Trust under ICANN’s accountability mechanism in October 2013. The IRP was administrated by the International Center for Dispute Resolution (ICDR) of the American Arbitration Association (AAA) New York, US.
DCA Trust had passed all the new gTLD applicant evaluation criteria, but before the Initial Evaluation (IE) result was issued, a Governmental Advisory Committee GAC Objection Advice that had been issued in Beijing in April 2013 was later accepted by the ICANN Board in early June 2013 which caused the ICANN Board to instruct ICANN staff that DCA Trust’s .Africa new gTLD application will not be approved. This had caused the non-completion of the evaluation of DCA Trust’s application; which then led DCA Trust to challenge the ICANN Board decision through a series of accountability mechanism.
Africa is an epic poem in Latin hexameters by the 14th century Italian poet Petrarch (Francesco Petrarca). It tells the story of the Second Punic War, in which the Carthaginian general Hannibal invaded Italy, but Roman forces were eventually victorious after an invasion of north Africa led by Publius Cornelius Scipio Africanus, the epic poem's hero.
Africa and De viris illustribus were partially inspired by Petrarch's visit to Rome in 1337. According to Bergin and Wilson (p. ix). It seems very likely that the inspirational vision of the Eternal City must have been the immediate spur to the design of the Africa and probably De viris illustribus as well. After returning from his grand tour, the first sections of Africa were written in the valley of Vaucluse. Petrarch recalls
The fact that he abandoned it early on is not entirely correct since it was far along when he received two invitations (from Rome and from Paris) in September 1340 each asking him to accept the crown as poet laureate. A preliminary form of the poem was completed in time for the laurel coronation April 8, 1341 (Easter Sunday).
Africa is 2009 Perpetuum Jazzile album. By large most successful song from the album is a capella version of Toto's "Africa", the performance video of which has received more than 15 million YouTube views since its publishing in May 2009 until September 2013.
Tumor susceptibility gene 101, also known as TSG101, is a human gene that encodes for a cellular protein of the same name.
The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.
The main role of ESCRT-I is to recognise ubiquitinated cargo via the UEV protein domain of the VPS23/TSG101 subunit. The assembly of the ESCRT-I complex is directed by the C-terminal steadiness box (SB) of VPS23, the N-terminal half of VPS28, and the C-terminal half of VPS37. The structure is primarily composed of three long, parallel helical hairpins, each corresponding to a different subunit. The additional domains and motifs extending beyond the core serve as gripping tools for ESCRT-I critical functions.
Vacuolar protein sorting-associated protein 45 is a protein that in humans is encoded by the VPS45 gene.
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators.
Charged multivesicular body protein 3 is a protein that in humans is encoded by the VPS24 gene.
This gene encodes a protein that acts in the sorting of transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants encoding different isoforms.
VPS24 has been shown to interact with IGFBP7.